L-Aspartamide, 1-acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-

Name	ATN-161
Synonyms	ATN161 ATN-161 ATN 161 ATN-161(free base) ATN-161 (Ac-PHSCN-NH2) AC-PRO-HIS-SER-CYS-ASN-NH2 L-Aspartamide, 1-acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl- (S)-2-((R)-2-((S)-2-((S)-2-((S)-1-Acetylpyrrolidine-2-carboxamido)-3-(1H-imidazol-5-yl)propanamido)-3-hydroxypropanamido)-3-mercaptopropanamido)succinamide
CAS	262438-43-7

Molecular Formula	C23H35N9O8S
Molar Mass	597.64
Density	1.443±0.06 g/cm3(Predicted)
Boling Point	1297.2±65.0 °C(Predicted)
Solubility	10 mM in DMSO
pKa	9.14±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
In vitro study	ATN-161 interaction with the N-terminus of the β1 region of integrin α5β1 locks integrin α5β1 in its inactive conformation. At concentrations up to 100 μm, ATN-161 had no significant effect on tumor cell proliferation. However, ATN-161 can significantly inhibit the phosphorylation of MAPK, and the maximum inhibition of MAPK phosphorylation can be detected at 30 minutes after treatment at a concentration of 20 μm.
In vivo study	ATN-161 (Ac-PHSCN-NH2) is a 5-mer capping peptide derived from the cooperative region of fibronectin, which binds to α5β1 and αvβ3 in vitro to prevent breast cancer growth and metastasis. ATN-161 treatment can cause a significant reduction in tumor volume, dose-dependently, and can completely prevent or cause a reduction in the number and incidence of bone and soft tissue metastases. ATN-161 treatment can also lead to a decrease in phosphorylated MAPK expression in vivo, a decrease in microvessel density and cell proliferation during tumor growth. ATN-161 has a relatively short half-life in plasma. The relatively long half-life in tumors suggests that the peptide plays a role in tumors through a long-lasting interaction with its target.

biological activity	ATN-161 (Ac-PHSCN-NH2) is a small peptide antagonist of integrin α5β1. It is capable of binding several integrins, including α5β1 and αvβ3, to play a role in angiogenesis and tumor progression.
Target	Value

Last Update：2024-04-09 20:52:54

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Product Name: ATN 161 Visit Supplier Webpage Request for quotation
CAS: 262438-43-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Product Name: ATN-161 Visit Supplier Webpage Request for quotation
CAS: 262438-43-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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L-Aspartamide, 1-acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl- Request for Quotation